A Rare Case of Concurrent Tropheryma Whipplei and Pneumocystis Jirovecii Pneumonia in a Patient During Endocrine Therapy for Breast Cancer
Abstract
Tropheryma whipplei (TW), a rare Gram-positive bacterium, is an uncommon cause of pulmonary infection, typically being reported in the context of gastrointestinal or neurological Whipple's disease. We present a case of a patient receiving endocrine therapy and ovarian suppression for breast cancer who developed a concurrent pulmonary infection with both Pneumocystis jirovecii (PJ) and TW. The diagnosis was secured through metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid, which successfully identified both pathogens. Following the initiation of targeted antimicrobial therapy, the patient exhibited significant clinical and radiological improvement.
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