Diagnostic accuracy of pulse pressure variation, stroke volume variation and plethysmography variability index for prediction of fluid responsiveness in anesthetized and mechanically ventilated dogs: a systematic review and meta-analysis
Abstract
OBJECTIVE
To assess the diagnostic accuracy of pulse pressure variation (PPV), plethysmographic variability index (PVI) and stroke volume variation (SVV) for predicting fluid responsiveness in dogs.
STUDY DESIGN
Systematic review and meta-analysis of diagnostic test accuracy studies.
ANIMALS
Anesthetized dogs undergoing surgery, in critical care, or in experimental settings.
METHODS
The study protocol was registered in Open Science Framework (https://doi.org/10.17605/OSF.IO/4DBGP). Databases (Medline, Embase, LILACS, Web of Science and Scopus) were searched from inception to 14 April 2025. Study quality was assessed using standardized criteria. Pooled sensitivity and specificity were calculated using a bivariate random-effects model. Likelihood ratios (LR), diagnostic odds ratios (DOR) and summary receiver operating characteristic (sROC) curves were generated. Confidence intervals (CIs) were calculated.
RESULTS
Risk of bias was high in all studies of PPV, PVI and SVV. In four clinical PPV studies, sensitivity was 0.88 (95% CI: 0.65-0.97), specificity 0.97 (95% CI: 0.83-0.99), LR+ 30.99 (95% CI: 5.25-182.85), LR- 0.11 (95% CI: 0.02-0.40) and DOR 263 (95% CI: 26-1890). In five experimental PPV studies, sensitivity was 0.78 (95% CI: 0.64-0.87), specificity 0.83 (95% CI: 0.70-0.91), LR+ 4.63 (95% CI: 2.41-8.88), LR- 0.27 (95% CI: 0.16-0.46) and DOR 17 (95% CI: 6-48). For PVI (five studies), sensitivity was 0.83 (95% CI: 0.75-0.89), specificity 0.85 (95% CI: 0.78-0.90) and DOR 29…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.