Effect of mussel‐inspired primers on resin–dentin bonding interface stability: A systematic review and meta‐analysis
Abstract
Abstract This paper presents the results of a systematic review and meta‐analysis on the efficacy of mussel‐inspired primers on resin‐dentin bond stability. This review was registered on the OSF platform (https://doi.org/10.17605/OSF.IO/QC7VU) and followed PRISMA guidelines. Databases included PubMed, SCOPUS, Web of Science, EMBASE, Lilacs, LIVIVO, and gray literature. Eligibility criteria included in vitro studies using human dentin, which assessed bond strength through microtensile tests after applying mussel‐inspired primers. Exclusion criteria were studies evaluating bond strength to enamel, animal dentin, and ceramics, those not using the microtensile test, or those conducting immediate evaluation only. The RoBDEMAT tool was used for risk‐of‐bias analysis. Two independent reviewers screened 5522 articles, and seven were selected. The studies showed a similar risk of bias performance, with insufficient reporting of different parameters, while not presenting significant publication bias. Meta‐analysis revealed significantly higher bond strength in specimens treated with mussel‐inspired monomers after thermocycling. Across studies, no substantial reduction in heterogeneity was observed using the leave‐one‐out method. Mussel‐inspired monomers incorporated into the dentin adhesive procedure can enhance bond strength, mainly through their catecholic groups, highlighting their potential in adhesive dentistry. However, drawbacks such as oxidative potential and effects on the…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.