Association of Ambient Air Pollution with Blood pressure in Adolescence: A Systematic-Review and Meta-analysis
Abstract
AIM
We systematically reviewed the association of ambient air pollution with blood pressure (BP) as a primary outcome in adolescents (10-19 years).
METHODS
Five databases (Ovid Medline, Ovid Embase, Web of Science, The Cochrane Library, and LILACS) were searched for relevant articles published up to August 2022. Meta-analyses were conducted using STATA v17 [Protocol - OSF Registries https://doi.org/10.17605/OSF.IO/96G5Q].
RESULTS
Eight studies (5 cohort, 3 cross-sectional) with approximately 15,000 adolescents were included. Data from six studies were suitable for inclusion in the meta-analysis. We found insignificant positive associations for cohort studies assessing long-term exposure to PM10, PM2.5, and NO2 on systolic and diastolic BP. At age 12 years old (3,799 participants), we found significant positive associations for long-term exposure to PM2.5 [β=5.33 (1.56, 9.09) mmHg] and PM10 [β=2.47 (0.10, 4.85) mmHg] on diastolic BP. Significant positive associations were observed (3,592 participants) for long-term exposure to PM10 [β=0.34 (0.19, 0.50) mmHg] and NO2 on diastolic BP [β=0.40 (0.09, 0.71) mmHg], and PM10 on systolic BP [β=0.48 (0.19, 0.77) mmHg]. The overall quality of evidence analysed was graded as "low/very low". Insufficient data for short-term exposures to PM2.5, PM10, NO2, CO on BP led to their exclusion from the meta-analysis. Inconsistent associations were reported for gender-stratified results.
CONCLUSION
The evidence, though of low-quality and limited,…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 15,000 participants or records.
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