P-020 Clinical outcomes of 583 treatment cycles with fresh and cryopreserved testicular sperm in cases without karyotype abnormalities and Y chromosome microdeletions needing testicular sperm extraction
Abstract
What are the embryological, clinical and newborn outcomes using fresh and cryopreserved testicular sperm in non-obstructive azoospermia patients? Are the differences between both techniques significant?
In this population there was a high live birth delivery rate with no significant differences observed in the outcomes using fresh and cryopreserved testicular sperm.
The use of cryopreserved testicular sperm has been considered of lower quality due to freezing/thawing consequences (1). Nevertheless, cryopreserved testicular sperm presents the advantages of avoiding female stimulation in cases of failed testicular sperm retrieval, or multiple testicular biopsies (2). However, the majority of the studies evidenced no significant differences in the clinical outcomes between the use of cryopreserved and fresh sperm (3). As only a few studies are dedicated to compare both techniques (4) we expanded the number of cycles and provided full demographic, stimulation, embryological, clinical and newborn outcomes.
References:
1- (https://doi.org/10.1016/j.cryobiol.2017.06.008)
2- (https://doi.org/10.1016/S1472-6483(10)60839-5)
3- (https://doi.org/10.1080/2090598X.2021.1932303)
4- (https://doi.org/10.1016/j.fertnstert.2008.04.051)
We retrospectively evaluated, during 20 consecutive years (2003-2023), 325 patients without karyotype abnormalities and Y-chromosome microdeletions, needing testicular sperm extraction. This study compares 583 ART treatment cycles, 503 with testicular sperm and…
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