A Pilot Clinical Trial of Repetitive Transcranial Magnetic Stimulation in Mild Cognitive Impairment
Abstract
Background: Mild cognitive impairment (MCI) is defined as a progressive memory dysfunction. There are controversies with regards to whether repetitive transcranial magnetic stimulation (rTMS) could improve the condition. Methods: In a randomized, self-control, crossover clinical trial, effect of rTMS on cognitive performance in patients with MCI was assessed. Patients were randomized into two study groups (A and B) and received both rTMS procedure and sham therapy in sequence, with each lasting for 8 weeks. Montreal cognitive assessment (MoCA) test was performed as a cognition battery at baseline and 1 week after each 8-week period of interventions. Results: Sixteen patients were enrolled in the study. Baseline measures of MoCA were statistically equal between two groups (P value = 0.10). Mean MoCA score significantly increased in group A at nine-week follow-up compared to both group B (P value < 0.001) and its baseline (P value = 0.01). However, at 18-week follow-up, mean MoCA scores were increased in both groups compared to their baseline (both P values < 0.001) with no significant differences between study groups (P value = 0.87). No adverse effects were reported. Conclusions: The rTMS is suggested as an effective and safe therapeutic option for cognitive improvement in patients with MCI. J Neurol Res. 2020;000(000):000-000 doi: https://doi.org/10.14740/jnr622
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.