Analysis of cardiovascular risk factors in a cohort of patients with ITP in a tertiary care center
Abstract
INTRODUCTION
There is a higher risk of thrombosis in ITP compared to general population, but little is known about the risk factors (RF) for thrombosis in these patients, except in splenectomises. Lambert et al1 (Eur J Haematol. 2023, DOI 10.1111/ejh.14154) report RF common to those in general population and emphasize the importance of personalized approach, with adequate control of comorbidities in these patients.
OBJECTIVE
To evaluate cardiovascular RF (RFCV) in a cohort of adults with ITP as part of their comprehensive care.
MATERIAL AND METHODS
Retrospective collection of data from electronic medical records of 55 adults followed in the outpatient clinic of 3rd level center. Data analysis with ChatGPT4o (OpenAI), which proposes statistical analyses based on the data collected. Our results are compared with those reported by Gonçalves et al2, RPTH (2024), https://doi.org/10.1016/j.rpth.2024.102342, Zhou et al3, Hematology (2025), https://doi.org/10.1080/16078454.2025.2472461 and Lambert et al.
RESULTS
We analised 31 men and 24 women. Mean Age ± SD: 63.4 ± 19.5 years, Median (IQR): 67.5 (47.0–78.0) years. Patients ≥60 years have higher prevalence of CVRF, use of agonists, and higher frequency of thrombotic events (27.3% vs 4.5%). Mean age of patients who suffer a thrombotic event is 77.6 years (median 79.0) vs. 60.2 years (median 64) for patients without thrombosis (p 0.0066, Mann-Whitney). Advanced age is a thrombotic RF in patients with ITP, similar to that reported in…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 55 participants or records.
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