A new opportunity for innovative inflammatory bowel disease research: the moderate-to-severe ulcerative colitis in Korea (MOSAIK) cohort study
Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 1 able economic burden for the healthcare system. The first costof-illness study for IBD in Korea reported an approximately 2-fold increase in total IBD-related direct healthcare costs over 5 years from $8.5 million in 2010 to $16.9 million in 2014. In addition to this “double burden” of the disease, UC is also associated with a significant psychosocial burden caused by debilitating symptoms that lead to poor health-related quality of life (HRQL) and loss of work productivity. Finally, patients with UC have a higher risk of developing colorectal cancers, compared with the general population. Given the chronic nature of UC, a comprehensive understanding of the natural history of UC is imperative for improving long-term care. In particular, identifying predictors of poor disease outcomes is essential for preventing disease progression and to efficiently use limited resources by optimizing personalized treatment strategies. In these regards, a prospective cohort study is an ideal research model for identifying the cause, and especially for understanding the natural history, of disease. Large-scale cohort studies in Europe and North America have demonstrated a changing landscape…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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