Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study
Abstract
Objective: To assess reticulin fibrosis in benign hematologic disorders and to understand the impact of benignhematologic disorders on the immune system.Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Hematology, Sheikh ZayedHospital, Lahore, Pakistan from January 2023 to June 2023.Methods: Patients who had benign hematologic disorders, such as iron deficiency anemia, MegaloblasticAnemia, Aplastic Anemia, and Immune Thrombocytopenic Purpura, were included in the research. Patientswith Malignant hematologic disorders and Individuals undergoing chemotherapy for any malignant diseasewere excluded. There were 96 cases total in the sample, 24 for each illness. Following processing in the histology department, the data for reticulin fibers were analyzed using bone marrow samples from the anterioriliac spine. An institutional ethics panel approved the research, and informed consent was acquired.Results: The study found that the gender distribution of cases was significantly different among the fourgroups. The average age of cases was not different among the four groups. Still, the Immune Thrombocytopenic Purpura group had the lowest average age of 40.5 years, and the Aplastic anemia group had the highest average age of 46.7 years. Among the hematological parameters, the hemoglobin level was the highest among the Immune Thrombocytopenic Purpura group, with an average of 10.8±1.9 g/dl. The median total leukocyte count for…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.