Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India
Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 149 Six patients with GIH were diagnosed over 1 year. Mean age was 43 ± 13.08 years (range, 25–60 years) and 3 patients (50%) were male. The presenting complaints in decreasing order were abdominal pain (5 patients), weight loss (5 patients), fever (4 patients), diarrhea (2 patients), dysphagia (2 patients) and hematochezia (1 patient). Two patients had HIV as a risk factor for GIH but none were previously diagnosed. One patient had history of gradually increasing dysphagia for last 6 months for which upper GI endoscopy was done which revealed presence of multiple deep ulcers in upper esophagus (Fig. 1A) and CT thorax showed long segment mild asymmetric circumferential thickening of mid-esophagus with multiple variable sized nodules in both lobes of lung and the histology was consistent with histoplasmosis (Fig. 1B). Other patient had intermittent colicky abdominal pain, for which contrast-enhanced CT (CECT) abdomen was done which revealed presence of circumferential mural thickening of terminal ileum, ileocecal (IC) junction and cecum. Colonoscopy showed circumferential ulcers in cecum. On evaluation they have been diagnosed with HIV with low CD4 counts (143 and 125…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 149 participants or records.
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