Endosalpingiosis in a Young Woman: A Rare Cause of Chronic Abdominal Pain – Case Report and Comprehensive Literature Review
Abstract
Background: Endosalpingiosis is a rare, benign gynecological condition characterized by ectopic
ciliated tubal-type epithelium located outside the fallopian tubes. While typically an incidental
finding during gynecological procedures, symptomatic presentations remain exceptionally
uncommon, particularly in younger women. A systematic review spanning the past decade
identified only 15 documented cases, with 93% occurring in postmenopausal women aged 50
years and above [1].
Case Presentation: We present an atypical case of symptomatic endosalpingiosis in a woman
in her early twenties presenting with chronic right-sided abdominal pain exacerbated by
menstruation. Diagnostic laparoscopy, performed to evaluate persistent symptoms and an
incidental appendicolith finding, revealed a small peritoneal nodule that was histologically and
immunohistochemically confirmed as endosalpingiosis.
Outcome: Following surgical excision and initiation of hormonal therapy with oral contraceptives,
the patient achieved complete symptom resolution and remained asymptomatic at 6-month
follow-up.
Clinical Significance: This case highlights the importance of recognizing endosalpingiosis
as a potential differential diagnosis in young women with unexplained chronic abdominal
pain, particularly when conventional diagnostic workup remains unrevealing. We discuss the
pathophysiological mechanisms, diagnostic challenges, treatment strategies, and significant
research gaps in the current literature.
Keywords:…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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