Examining lurasidone efficacy in schizophrenic patients with comorbid alcohol and substance USE disorder: a multicentric prospective investigation
Abstract
Abstract Background Alcohol/Substance Use Disorder (AUD/SUD) among schizophrenic patient represent a common and problematic co-occurrence, with a rate of comorbidity assessed between 40% and 70%, especially in young patients at the onset of their disorder (1-2). Comorbid patients are usually difficult to treat: they show a very low level of compliance, and are frequently exposed to drop-out and lack of efficacy for the available antipsychotic drugs leading to worsened clinical outcomes and increased difficulty in treatment (3-4). Aims & Objectives to evaluate the effectiveness and safety of the second generation antipsychotic lurasidone in schizophrenic patients comorbid AUD/SUD. Method In this prospective, multicentric, real-world study, a total of 21 patients (M/F ratio: 14/7; age=34.20 ± 11.81), diagnosed with Schizophrenia and AUD/SUD (6 and 15, respectively) were recruited and treated using lurasidone up to 148mg/day. Evaluations were performed at the baseline (T0) and after 4 weeks (T1) using Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression-Improvement (CGI-I) scores. Quality of life (Q-LES-Q-SF), alcohol and substance related aggressiveness (Modified Overt Aggression Scale/MOAS), as well as craving for substances (VAS) were assessed. Repeated-measures ANOVA (rm-ANOVA) models were used to estimate the effect of treatment on the aforementioned psychometric scales. Results Lurasidone was effective in reducing the total burden of…
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