P0414 Serum Activin-A level as a new biomarker in active Ulcerative Colitis patients
Abstract
Ulcerative colitis is a lifelong inflammatory disease affecting the rectum and colon to varying degrees. Multiple scoring-classification methods, including endoscopic, clinical, and combined methods, have been used to assess disease severity. Various biomarkers are used for diagnosis and subtyping in ulcerative colitis, including fecal calprotectin, C-reactive protein, p-ANCA, ESR, anti-integrin αvβ6, and serum trefoil factor 3. In this study, we investigated whether there was a significant difference in serum activin-A levels, considered an indicator of intestinal inflammation, between symptomatic active ulcerative colitis patients and a control group.
The study included 34 patients and 18 controls, Patients were analyzed for serum Activin-A levels, symptomatic assessment, endoscopic evaluation, and laboratory parameters.
Serum Activin-A levels in the patient group were significantly higher than those in the control group (p=0.034). Accordingly, with a sensitivity of 55.9% and a specificity of 72.2%, the cut-off value for Activin-A was found to be 486.925 pg/mL.
Serum activin A level has been associated with active ulcerative colitis
Namwanje M, Brown CW. Activins and inhibins: roles in development, physiology, and disease. Cold Spring Harb Perspect Biol. 2016;8(7):a021881. https://www.doi.org/10.1101/cshperspect.a021881
Sonoyama K, Rutatip S, Kasai T. Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells. Am J Physiol Gastrointest…
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.