More-Than-Partial Entrustment in Pragmatic Clinical Trials
Abstract
improve kidney outcomes in children with Shiga toxinproducing E. coli infection: A multinational embedded cluster crossover randomized trial (the HIKO STEC trial). Trials 24: 359. https://doi.org/10.1186/s13063-023-07379-w. Garland, A., S. Morain, and J. Sugarman. 2023. Do clinicians have a duty to participate in pragmatic clinical trials? The American Journal of Bioethics 23 (8):22–32. doi: 10.1080/15265161.2022.2146784. Hickey, C. A., T. J. Beattie, J. Cowieson, Y. Miyashita, C. F. Strife, J. C. Frem, J. M. Peterson, L. Butani, D. P. Jones, P. L. Havens, et al. 2011. Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome. Archives of Pediatrics & Adolescent Medicine 165 (10):884–9. doi:10.1001/archpediatrics.2011.152. Magnus, D., and B. S. Wilfond. 2015. Research on medical practices and the ethics of disclosure. Pediatrics 135 (2): 208–10. doi:10.1542/peds.2014-3578. McKee, R. S., D. Schnadower, P. I. Tarr, J. Xie, Y. Finkelstein, N. Desai, R. D. Lane, K. R. Bergmann, R. L. Kaplan, S. Hariharan, et al. 2020. Predicting hemolytic uremic syndrome and renal replacement therapy in Shiga toxin-producing Escherichia coli-infected children. Clinical Infectious Diseases 70 (8):1643–51. doi:10.1093/ cid/ciz432. Mody, R. K., W. Gu, P. M. Griffin, T. F. Jones, J. Rounds, B. Shiferaw, M. Tobin-D’Angelo, G. Smith, N. Spina, S. Hurd, et al. 2015. Postdiarrheal hemolytic uremic syndrome in United States children: Clinical…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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