Candida auris infections in China
Abstract
First described in 2009 in Japan, the multidrug-resistant human fungal pathogen Candida auris represents a new global public health threat [1,2]. As of February, 2021, C. auris cases have been reported in over 40 countries across six continents, with several outbreaks occurring simultaneously in different hospitals [3–6]. C. auris is often called a “superbug” due to its multidrug-resistant and highly transmissible features. Some clinical isolates are even resistant to all three of the major classes of antifungal drugs (the azoles, the polyenes, and the echinocandins) [2,7]. In 2019, the Centers for Disease Control and Prevention (CDC) placed C. auris on the list of urgent threats (Antibiotic Resistance Threats in the United States, 2019; https://www.cdc.gov). In 2018, we isolated the first C. auris strain in China from a 76-year-old hospitalized female patient with hypertension and nephritic syndrome in Beijing, China [8]. The strain (BJCA001) was recovered from the bronchoalveolar lavage fluid (BALF) of the patient, identified by matrix-assisted laser desorption/ionization-timeof-flight (MALDI-TOF) mass spectrometry, and verified using internal transcribed spacer (ITS) sequencing analyses. Interestingly, the strain BJCA001 exhibited notably low minimal inhibitory concentrations (MICs) for all tested antifungal drugs. Subsequently, Chen et al. (2018) reported two cases of bloodstream infections caused by fluconazole-resistant C. auris in the Army General Hospital (Beijing,…
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