Preparation of Aspirin Nanosuspension by Antisolvent Precipitation Method
Abstract
This study aims to enhance the dissolution rate of a poorly-soluble drug, aspirin, by fabricating aspirin nanosuspensions using the anti-solvent precipitation. The study investigates the effect of the type of solvents, solvent to anti-solvent ratio, drug concentration, machines, stirring speed, ultrasonication technique and the temperature of solvent on the particle size and polydispersity index. The characterization of the original aspirin powder and nanoparticles was evaluated by differential scanning calorimetry and in vitro dissolution test. The results indicate that the selected formulation showed the smallest mean size of 228.2 ± 24.6 nm and a zeta potential of - 40.3 ± 2.5 mV. The differential scanning calorimetry analysis demonstrates that aspirin nanoparticles possessed lower crystallinity than the raw aspirin powder. The dissolution of nanoparticle was significantly higher compared with the original drug in the in vitro dissolution test.
Keywords: Aspirin, nanosuspension, anti-solvent precipitation, differential scanning calorimetry, dissolution.
References
[1] G. C. Curhan, A. J. Bullock, S. E. Hankinson, W. C. Willett, F. E. Speizer, M. J. Stampfer, Frequency of Use of Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Aspirin in US Women, Pharmacoepidemiol Drug Saf, Vol. 11, No. 8, 2002, pp. 687-693, https://doi.org/10.1002/pds.732.[2] Antithrombotic Trialists (ATT) Collaboration, Aspirin in the Primary and Secondary Prevention of Vascular Disease:…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
Read the paper
Related studies
- In silico strategies for modeling RNA aptamers and predicting binding sites of their molecular targets
- Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery
- Anti-phytopathogenic and plant growth promoting potential of endophytic fungi isolated from Dysoxylum gotadhora
- Mercury toxicity causes iron and sulfur deficiencies along with oxidative injuries in alfalfa (Medicago sativa)
- Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo
- Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.