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AWaRe antibiotic prescribing for common acute infections in low-middle income countries – a patient level analysis using IQVIA prescriber surveys from Pakistan, Egypt and Indonesia

Nam Nguyen, Sherry Mangla, Peter N Stephens, Aislinn Cook, Mike Thorn, Zikria Saleem, Siswanto Agus Wilopo, Elizabeth Tayler et al.

medRxiv, 2025

Abstract

ABSTRACT Background There is limited large-scale and high-quality data on antibiotic prescribing in low- and middle- income countries (LMICs), particularly in the private sector. Here we use healthcare surveys to assess antibiotic prescribing levels and the factors influencing prescribing decisions for common infections in primary care and outpatient settings, predominantly within the private sector, in Pakistan, Egypt, and Indonesia. Methods We analysed surveys completed by prescribers in Pakistan, Egypt, and Indonesia, collected in primary care and outpatient settings, predominantly within the private sector, by IQVIA between 2017 and 2021, namely IQVIA’s proprietary Medical Data Index (Medical Index of Pakistan (MIP), Egypt Medical Data Index (EMDI) and Indonesia Medical Data Index (IMDI)). IQVIA market research information reflects estimates of real world activity and should be treated accordingly. We evaluated antibiotic prescribing categorized by WHO AWaRe and Essential Medicines List (EML) classifications for common infections. We used mixed-effects regression analyses to identify factors influencing prescribing decisions. Results Among the 384,975 infection-related health consultation records analysed, antibiotics were prescribed overall in 82.0% of consultations in Pakistan, 81.2% in Egypt, and 69.1% in Indonesia. Watch antibiotics accounted for 70.2% of all antibiotic prescriptions in Pakistan, 52.9% in Egypt, and 53.6% in Indonesia. Non-WHO EML antibiotics…

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