Efficacy and safety of sequential IV/PO moxifloxacin for the treatment of severe community-acquired pneumonia
Abstract
The oral form of moxifloxacin (MXF) has been used in 9 million patients and has been demonstrated to be an effective and well tolerated treatment for respiratory tract infections in extensive clinical trials. An IV formulation of MXF has been developed and recently was approved in the US for the treatment of community-acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and uncomplicated skin and skin structure infections. The efficacy and safety of IV/PO MXF compared with IV/PO comparator (CMP) in CAP was examined in two randomized, controlled studies; a pooled analysis of the patients with severe CAP is reported here. In both studies, MXF-treated patients received 7–14 days IV/PO MXF 400 mg QD. In study 1, CMP-treated patients received IV/PO alatrofloxacin/trovafloxacin 200 mg QD or IV/PO levofloxacin 500 mg QD; in study 2, CMP-treated patients received IV/PO amoxicillin clavulanate 1200/625 mg TID ± IV/PO clarithromycin 500 mg BID. Severe CAP was defined as the presence of at least one of the following conditions: respiratory rate >30 breaths/min; P a O 2 /FIO 2 ratio < 250 mmHg or PO 2 ≤ 8 kPa (60 mmHg); requirement for mechanical ventilation; chest radiograph indicating bilateral or multilobe involvement; increase in the size of opacity by ≥ 50% within 48 hours of admission; or shock (systolic blood pressure <90 mmHg or diastolic pressure <60 mmHg). One hundred and ninety MXF-treated and 186 CMP-treated patients comprised…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 9 participants or records.
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