Vildagliptin Compared to Glimepiride in Combination With Metformin in Patients With Type 2 Diabetes
Abstract
Many people with type 2 diabetes cannot maintain target blood glucose levels when taking a single oral drug. The purpose of this study is to assess the long term safety and effectiveness of vildagliptin, an unapproved drug, compared to that of glimepiride in lowering overall blood glucose levels when added to metformin in people with type 2 diabetes not at target blood glucose levels on metformin alone.
Conditions: Diabetes Mellitus, Type 2.
Primary outcome: Time to HbA1c >8%.
Enrollment: 3118 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 3,118 participants or records.
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