Local Injections of Fluorouracil for Eyelid Hordeolum
Abstract
Hordeolum is usually self-limited, but a subset of patients develop persistent, symptomatic induration or prefer to avoid incision and curettage in the cosmetically sensitive eyelid. Currently, treatment methods for hordeolum mainly include local warm compresses, local or systemic antibiotic therapy, and abscess incision and drainage. We describe a small case series of 4 female patients with eyelid inflammatory nodules within the hordeolum-chalazion spectrum treated with local injection of 6-fold diluted 5-fluorouracil. Clinical response and adverse events were recorded. Two patients achieved complete clinical resolution within 3 to 7 days after a single injection. One bilateral case improved rapidly after the initial injection; the right-sided lesion resolved by day 7, whereas a left-sided induration persisted despite a second injection and remained essentially unchanged at follow-up. One long-standing post-incision-and-drainage case showed marked reduction by day 2 and further improvement by day 7 but did not completely resolve. No treatment-related adverse events were observed, and no recurrence was noted in cases with complete resolution during follow-up. Local injection of 6-fold diluted 5-fluorouracil may represent a potential minimally invasive option for selected patients with persistent eyelid inflammatory nodules. Responses were variable in this small uncontrolled series; further controlled studies are warranted to clarify efficacy, optimal dosing, and safety.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.