Efficacy of leucine-rich high protein supplementation on body composition and muscle function among older adults with sarcopenia: a randomized controlled trial
Abstract
Purpose: To evaluate the effect of leucine-rich high protein supplementation on body composition, muscle function and gene expression among older adults with or at risk of sarcopenia residing in Klang Valley, Malaysia.
Methods: A total of 47 participants were recruited into this 12-week double-blinded, randomized controlled trial. Intervention group consumed 2 sachets of high protein supplement daily contributing to 50.6 g of protein/day and 6 g of leucine/day. Control group received placebo supplement. Body composition was assessed via anthropometry measurements, bioelectrical impedance analysis (BIA), and magnetic resonance imaging (MRI) of left mid-thigh. Meanwhile, muscle function was assessed using short physical performance battery (SPPB). A total of 16 ml of full blood was collected pre- and post- study to assess participants' health profiling and changes in gene expression as determined by mitochondrial RNA activity derived from the peripheral blood mononuclear cells. The measurements were performed at 0, 6, and 12 weeks.
Results: Participants were mostly women (89.4%) with a mean age of 69.3 ± 7.1 years. Repeated measures ANOVA showed no significant intervention effect in body composition (anthropometry measurements and BIA) as well as muscle function (SPPB score). However, genes responsible for adenosine triphosphate (ATP) production (GBA, MLYCD), cell proliferation (STAT5A) and DNA repair (BRCC3) were significantly up-regulated in intervention group (p < 0.05).…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 47 participants or records.
Read the paper
Related studies
- Chaos and quantum thermalization
- The Dalton quantum chemistry program system
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study
- Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
- Stable adiabatic quantum batteries
- A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.