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Effect of high dietary lysine on growth performance and body composition in weaned pigs following a period with dietary protein restriction: a preliminary study

Ruggeri R, Girard M, Silacci P, Bee G, Larsen C, Madsen JG

Journal of animal science, 2026

Abstract

Increasing dietary Lys and remaining essential amino acids (AA) above requirements might counter impaired growth resulting from pigs being fed a low-protein (LP) diet in the early weaning period. It was hypothesized that by increasing dietary Lys and remaining essential AA levels in a 4-week (W) non-reduced period (W5-8) after a 4-W reduced dietary crude protein period (W1-4) would potentially increase growth performance. At weaning, 67 piglets with an ADG of 200-220 g/day during the suckling period were selected based on their weaning weight for the study. On the day of weaning pigs were pre-allocated to 1 of 4 dietary treatments: control (STD-STD), standard (LP-STD), STD + 10% Lys (LP-STD10+) and STD + 20% Lys (LP-STD20+). From weaning to W4 after weaning LP-STD, LP-STD10+ and LP-STD20+ pigs were fed the same LP starter diet (81/79% total/digestible of CP level in STD diet), whereas STD-STD pigs were fed a diet formulated according to recommendations. From W5 to W8 after weaning LP-STD pigs were fed a diet with standard protein level, and LP-STD10+ and LP-STD20+, respectively, fed a diet with STD protein level plus 10% and 20% Lys including remaining essential AA. One day before weaning, and at W4, and at W8 after weaning, respectively, seven pigs (baseline Dual‑energy X‑ray absorptiometry (DXA) scanning), six STD and six LP pigs, and 12 STD-STD, 12 LP-STD, 12 LP-STD10+ and 12 LP-STD20+ pigs were slaughtered to DXA scan the carcasses. The data were analyzed using the ANOVA…

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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