Effects of microbial phytase on mucin synthesis, gastric protein hydrolysis, and degradation of phytate along the gastrointestinal tract of growing pigs
Abstract
An experiment was conducted to test the hypothesis that pigs fed diets supplemented with exogenous phytase reduce mucin synthesis in the small intestine, increase protein hydrolysis in the stomach, increase breakdown of phytate along the gastrointestinal tract, and increase mineral and AA digestibility. A diet based on corn, soybean meal, and canola meal was formulated to meet requirements for growing pigs except for Ca and P, which were lower than requirements. Three additional diets were formulated by adding 750, 1,500, or 3,000 units of phytase (FTU) per kilogram to the basal diet. Eight growing barrows (38.45 ± 3.06 kg) were prepared with a T-cannula in the duodenum and another T-cannula in the distal ileum. Pigs were housed individually and allotted to a replicated 4 × 4 Latin square design with four pigs and four periods in each square. Each period lasted 14 d with the initial 7 d being the adaptation period to the diets. Pigs were fed twice daily in combined amounts equal to 3.2 times the estimated requirement for maintenance energy. Results indicated that the apparent ileal digestibility (AID) and the apparent total tract digestibility (ATTD) of Ca and P increased (linear and quadratic, P ≤ 0.05) as phytase inclusion increased. However, values for AID of Ca and P were not different from values for ATTD of Ca and P, indicating that there is no net absorption of Ca and P in the hindgut. The apparent duodenal digestibility (ADD) of Ca and P was ~30% and 10% to 20%,…
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Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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