Changes in body weight, adherence and appetite during 2 years of calorie restriction: The CALERIE 2 randomized clinical trial
Abstract
Background/objectives The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study showed that individuals who are nonobese were able to undergo significant calorie restriction (CR), yet the time course changes in adherence, weight, and appetite are unknown. This analysis aimed to investigate the time course changes in adherence, body weight, and appetite during the CALERIE study. Subjects/methods Overall, 143 participants (body mass index: 21.9–28.0 kg/m 2 ) were randomized to a CR group that aimed to achieve 25% CR for 2 years. Throughout the intervention, body weight was measured, and appetite was assessed through visual analogue scales. Algorithms were utilized with body weight measurements to calculate adherence percentile score. Participants targeted an adherence percentile score of 50, though being between 80 (lowest acceptable adherence) and 10 (highest acceptable adherence) was adequate. Polynomial regression analyses were used to assess time course changes. Results Polynomials indicated that adherence percentile score increased above 50 after approximately week 20, although adherence remained acceptable (adherence percentile score less than 80) ( R 2 = 0.89; P < 0.001). Weight loss occurred until approximately week 60 and then plateaued ( R 2 ≥ 0.92; P < 0.001). Hunger and thirst increased ( R 2 ≥ 0.30; P < 0.001), but the total increase in scale scores were <10 mm throughout the intervention. Conclusions In individuals who…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 143 participants or records.
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