Photobiomodulation therapy for children’s eye and vision conditions
Abstract
Abstract Background: Photobiomodulation (PBM) is a non-invasive, light-based technology that stimulates cellular mechanisms, with therapeutic effect on a variety of medical conditions. Wavelengths of light are absorbed by intracellular photoreceptors, resulting in the activation of signalling pathways that culminate in biological changes within the cell. PBM treatment has been reported for a range of eye/vision conditions, mostly in adults. Objectives: We carried out a scoping review of the published literature and collated reported uses of PBM for eye/vision/lid/orbital conditions in children and young people. Eligibility criteria: We developed a comprehensive Ovid Medline, Ovid Embase and Cochrane Library search strategy. We included primary research articles written in English reporting an age range from 0-18 years. Ocular, vision, lid, or orbital conditions treated with PBMT, low light therapy, or intense pulsed light therapy (400–1100 nm spectral range). Case reports, meta-analyses, systematic reviews, and studies using photodynamic therapy, cross-linking, or optogenetics were excluded. Sources of evidence: We used Covidence Systematic Review Software for de-duplication and screening of titles and abstracts, using a pre-specified screening tool. Charting methods: We developed and used a data extraction tool in Covidence. Two reviewers independently extracted data and discussed and resolved disagreements. Results: Of 5,081 identified studies, 47 were included. The…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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