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Lactic acidosis induced by excessive ingestion of metformin

Bismuth C, Gaultier M, Conso F, Assan R, Heuclin C

European journal of toxicology and environmental hygiene. Journal europeen de toxicologie, 1976

Abstract

The authors report on a case of lethal lactate acidosis during acute metformine and barbiturate poisoning. The study of energetic substrates and glucoregulation hormones demonstrated a blockade of hepatic gluconeogenesis.

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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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