Formation of fructosamine in diabetic patients - what are implications in terms of energy exchange
Abstract
SUMMARY Diabetes mellitus is a frequent disorder affecting individuals of all ages. Monitoring by biomarkers has a key role in the assessment of glycemic control in diabetic patients. Fructosamine is used routinely to assess long term glycemic control in patients with diabetes mellitus. The chemical reaction of glycosylation in the formation of fructosamine has been described for decades. Here, a reappraisal of the bonding energy based on quantum chemical analysis was performed. The bonding energy of the reaction was calculated, showing it to be of the “energy consuming reaction” type. Of interest, the required energy for complex formation per mole of the reaction was equal to that previously reported in the reaction of hemoglobin A 1c (HbA 1c ) formation. This could confirm the nature of energy loss in patients with poorly controlled diabetes mellitus.
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