Studies in Animal Models of Atherosclerosis
Abstract
1. Alterations in vascular function have been investigated in two clinically relevant situations - atherosclerosis and exposure to free radicals / reactive oxygen species. Two animal models of atherosclerosis were studied - the cholesterol fed New Zealand White rabbit and the genetically hyperlipidaemic WHHL rabbit. The in vitro model for free radical / reactive oxygen species exposure was investigated in aortic tissue from New Zealand White rabbits. Contractile and relaxant properties of the vasculature were examined in these models.
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Evidence Hub reads this as a thesis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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