Two selective fluorescent chemosensors for cadmium ions in 99% aqueous solution: the end group effect on the selectivity, DFT calculations and biological applications
Abstract
Two fluorescent chemosensors for cadmium ions, 2-(2-formylquinolin-8-yloxy)-N,N-diisopropylacetamide (FQDIPA) and 2-(2-formylquinolin-8-yloxy)-N,N-diphenylacetamide (FQDPA), were first assessed in 99% aqueous solutions. The sensor FQDIPA with an end group of an aliphatic amine can recognize Cd(2+) from other metal ions more selectively and sensitively than FQDPA with that of aromatic amines, which was further demonstrated by DFT calculations that were comparable to the experimental results. It is indeed the distinction between the end groups of these chemosensors that results in the variation of the energy difference between the LUMOs and HOMOs and the interaction energies of FQDIPA·Cd(2+) and FQDPA·Cd(2+). Furthermore, the living cell image experiment could also indicate that the FQDIPA is more suitable than the FQDPA in the practical applications in biological systems.
How strong is the evidence?
Evidence Hub reads this as a simulation / modelling, done in cell cultures (in vitro), not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Chaos and quantum thermalization
- The Dalton quantum chemistry program system
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort Study
- Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes
- Stable adiabatic quantum batteries
- A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.