High prevalence of blaNDM gene among a series of carbapenem-resistant Enterobacterales isolates from children less than one year old in Niger
Abstract
BACKGROUND: Carbapenem-resistant Enterobacterales are increasingly reported worldwide, posing significant treatment challenges, especially in vulnerable pediatric populations. This study describes the molecular epidemiology and antimicrobial susceptibility of carbapenem-resistant Enterobacterales isolated from infants under one year of age in Niger. This prospective case series reports on 14 children < 1 year old with carbapenem-resistant Enterobacterales isolates. RESULTS: A total of 14 isolates were analyzed, predominantly Escherichia coli (78.6%; n = 11), followed by Serratia odorifera (7.1%, n = 1), Klebsiella pneumoniae (7.1%, n = 1), and Klebsiella oxytoca (7.1%, n = 1). The blaNDM gene was the most frequently detected carbapenemase, found in 7 isolates (50.0%), followed by blaVIM in 4 isolates (28.6%), blaKPC in 2 isolates (14.3%), and blaOXA−48 in 1 isolate (7.1%). High resistance rates to fluoroquinolones and aminoglycosides were observed, with moderate fosfomycin activity. Cefiderocol, tigecycline, and eravacycline demonstrated preserved activity across carbapenemase genotypes, whereas ceftazidime–avibactam showed limited activity against metallo-β-lactamase producers. An apparent relationship between carbapenemase genotype and multidrug resistance phenotype was observed. CONCLUSIONS: Carbapenem-resistant Enterobacterales isolates in infants under one year of age represent a major clinical challenge in Niger. The predominance of blaNDM producing organisms, combined…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 14 participants or records.
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