Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking
Abstract
The Neotropical stink bugs Euschistus heros and Diceraeus melacanthus are major pests of soybean and maize in South America, yet current chemical control strategies face widespread resistance, highlighting the urgent need for sustainable alternatives. This study investigates Ficus carica pruning residues as a source of selective botanical insecticides, integrating optimized extraction, phytochemical profiling, bioassays, and molecular modeling. Eight extracts were prepared under varying solvent, temperature, and acidity conditions, and analyzed for total phenolic content (TPC) and the key furanocoumarins psoralen and bergapten. Acidification enhanced overall mass yields, while mild ethanol extraction at room temperature selectively maximized furanocoumarin recovery, yielding psoralen concentrations up to 14.83 mg g-1, which is substantially higher than previously reported in leaves or fruit. Biological evaluation of the optimized ethanolic extract (ERA) revealed strong insecticidal activity, with 86% mortality of E. heros and 40% of D. melacanthus nymphs at 48 h, and a calculated LC50 of 1232 mg L-1 for E. heros. The differential susceptibility between species suggests both metabolic and cuticular factors influence efficacy. Computational docking and phylogenetic analyses suggested a potential mechanistic basis for the observed selectivity: furanocoumarins are predicted to bind hemipteran AChE via a compensatory polar scaffold, whereas binding to Apis mellifera AChE is…
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