Development of simultaneous PET and Compton imaging using GAGG-SiPM based pixel detectors
Abstract
Abstract Positron emission tomography (PET) is considered an important and powerful tool for molecular imaging and medical diagnosis with its high sensitivity. Further, single-photon emission CT (SPECT) is another important imaging modality providing different types of information in medical diagnosis. On the other hand, Compton imaging is a promising technique for future molecular imaging with multi-nuclides based on Compton scattering kinetics. In this regard, previously, we have developed gadolinium aluminum gallium garnet (GAGG)-scintillation-based PET systems and GAGG-scintillation-based Compton imaging systems for environmental applications. Here, we propose and develop a novel PET–Compton hybrid simultaneous imager based on a two-layer structure using thin scatterers and thick absorbers for multi-nuclide imaging, for e.g., simultaneous imaging of PET and SPECT tracers such as 18F-FDG and 111In, respectively. For achieving good spatial resolution of the Compton imager, the energy resolution of the utilized scintillators forms one of the most important characteristics. In this regard, GAGG is a promising scintillator because of its high light yield of over 50 000 photon/MeV and excellent energy resolution of 4% with no background radiation and moderate decay time. In this study, we present the development of a simultaneous PET–Compton detector that consists of an 8 × 8 multi-pixel photon counter/SiPM (MPPC) array individually coupled with a 2.5 × 2 . 5 × 9-mm 3 Ce:Gd 3…
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