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Role of Vonoprazan-Amoxicillin Dual Therapy in Pediatric Refractory Helicobacter Pylori Infection in Children: Early Experience From A Single-Center Case Series

Cardenas Fernandez MC, Ruiz Arellanos K, Bonilla S

ACG case reports journal, 2025

3 citations

Abstract

ABSTRACT This small case series presents real-world experience on the efficacy of dual therapy with vonoprazan and amoxicillin in pediatric patients with refractory, antimicrobial-resistant Helicobacter pylori infection and highlights the role of adequate acid suppression in treatment success. Dual therapy with vonoprazan and amoxicillin was well tolerated and resulted in successful eradication in all patients.

How strong is the evidence?

Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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