Iodine-131 whole gamma imaging outperforms clinical SPECT
Abstract
Whole gamma imaging (WGI), which is a novel combination of PET and Compton imaging, may have a potential to replace conventional single photon emission computed tomography (SPECT) by Compton imaging, but nobody has ever demonstrated it. As the first trial, this work aimed at imaging 131I. 131I is a theranostic radioisotope which emits β-particles and γ-rays. Although in vivo imaging is possible by a clinical gamma camera, the spatial resolution and the sensitivity are limited due to the high energy (364 keV) of the γ-rays. On the other hand, Compton imaging has the potential to become a novel imaging modality in nuclear medicine because it can visualize γ-rays with a wide energy range. In this study, we used a WGI prototype system consisting of a dual ring of GSOZ scintillation detectors. In addition, we compared the imaging performance with that of a clinical gamma camera. Using a stereolithography-type 3D printer, we developed two phantoms having outer diameters of 76 mm. A multi-rod phantom (rod diameters: 3, 4, 5, 8 and 10 mm) was developed for spatial resolution evaluation. A multi-contrast phantom was developed for image contrast evaluation. Two 20 mm rod regions were placed inside the phantom. The phantoms were filled with 131I solutions and then were measured by the WGI prototype system and the clinical gamma camera (30-min measurement each). The 5 mm rods were resolved in the 131I Compton images, while the clinical gamma camera could not resolve them. Hot and cold…
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