Prevalence and factors associated with microvascular and macrovascular diabetes complications in adult Ugandans: A systematic review and meta-analysis
Abstract
Introduction: The rising prevalence of diabetes in Uganda has led to a disproportionate increase in the burden of diabetes complications. We conducted a systematic review and meta-analysis to document the prevalence and factors associated with five chronic diabetes complications in adult Ugandans with diabetes.
Methods: We searched Medline, EMBASE, CINAHL, Cochrane Library, and Africa Journal Online databases from 25th May 2024-29th May 2024. We included studies reporting information on the prevalence and factors associated with the five chronic diabetes complications. We conducted a random-effect meta-analysis to determine the pooled prevalence of each diabetes complication. Using narrative synthesis, we described the factors significantly associated with each diabetes complication.
Results: A total of twenty studies reporting information on 11,400 participants were considered. The pooled mean (standard deviation) age of the participants was 54.8 (3.6) years. For the microvascular diabetes complications, the pooled prevalence of diabetic neuropathy, retinopathy, and nephropathy was 56.8% (95% CI 44.9-68.7, I2 = 98.56%, p 60 years were associated with diabetic neuropathy, while female sex, hypertension comorbidity, and use of glibenclamide were associated with peripheral arterial disease.
Conclusions: This study demonstrates a high prevalence of chronic diabetes complications in adult Ugandans with diabetes. Timely screening and optimal management of chronic diabetes…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 11,400 participants or records.
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