Refractive Lensectomy in Patients with Fuchs' Endothelial Dystrophy
Abstract
PURPOSE
The aim of this retrospective study was to evaluate the outcomes of refractive lens exchange (RLE) with implantation of extended depth of focus (EDOF) and trifocal intraocular lenses (IOLs) in presbyopic hyperopic patients diagnosed with Fuchs endothelial corneal dystrophy (FECD), and to retrospectively assess preoperative criteria suitable for RLE indication.
MATERIALS AND METHODS
The study included 17 patients (34 eyes) with hyperopia and FECD who underwent RLE with implantation of EDOF or trifocal IOLs at Lexum Eye Clinics between 2022 and 2024. The mean follow-up period was 13 months, and the mean patient age was 56 ±5 years. Evaluated parameters included preoperative and postoperative refraction, visual acuity, endothelial microscopy, central pachymetry, and posterior corneal backscatter.
RESULTS
The mean preoperative uncorrected distance visual acuity was 0.68 logMAR, improving postoperatively to 0.01 logMAR. The mean corrected distance visual acuity improved from 0.01 logMAR preoperatively to -0.01 logMAR postoperatively. Postoperative uncorrected intermediate and near visual acuities were 0.07 logMAR and 0.10 logMAR, respectively. According to Krachmer's classification of endothelial microscopy, 14 patients had grade 1, one patient grade 2, and two patients grade 3 FECD. The mean postoperative endothelial cell density was 2595 cells/mm², with a coefficient of variation of 30 % and hexagonality of 50 %. No statistically significant difference was found between…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 17 participants or records.
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