Densitometry Analysis of Corneal Backscatter After Pre-Descemet Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy
Abstract
PURPOSE
To quantify corneal backscattering by densitometry analysis after pre-Descemet endothelial keratoplasty (PDEK).
DESIGN
This is a prospective observational case series.
METHODS
Setting: Tertiary care hospital.
PARTICIPANTS
Postoperative PDEK eyes with best-corrected visual acuity (BCVA) ≥20/40 without comorbidity.
OBSERVATION PROCEDURE
Slit-lamp examination, Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany), endothelial cell density (cells/mm), and central corneal thickness (Visante; Carl Zeiss AG, Oberkochen, Germany) were performed. Corneal densitometry values for the entire depth of the cornea were compared between post-PDEK eyes and fellow eyes (non-PDEK).
MAIN OUTCOME MEASURES
Mean densitometry (grayscale units, GSUs) of the anterior, posterior, central, total depth and concentric zones (0-2, 2-6, 6-10, and 10-12 mm) of the cornea.
RESULTS
Overall, 35 eyes (21 PDEK eyes and 14 control eyes) were evaluated. The mean total densitometry values in the anterior, central, and posterior corneas were 40.7 ± 7.6 GSU, 25.3 ± 4.8 GSU, and 20.9 ± 3.4 GSU, respectively. On inter-zone comparison between central and peripheral cornea, there was a statistically significant difference (P < 0.05) between 0 to 2 mm and 6 to 12 mm zones. There was no correlation between endothelial cell density and central corneal thickness with densitometry. However, there was a significant correlation of BCVA with corneal densitometry in 0 to 2 mm (r = 0.519, P = 0.016) and 6 to 2 mm (r =…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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