Evaluation of corneal and lens densitometry in children with familial Mediterranean fever
Abstract
BACKGROUND
This study aimed to investigate the presence of subclinical inflammation in the eye by examining corneal and lens changes in children with familial Mediterranean fever (FMF) and provide the regulation for follow-up and treatment protocols according to the presence of signs of inflammation.
DESIGN
This is a cross-sectional, case-control study.
METHODS
Topographic parameters and corneal and lens densitometry of 48 patients with FMF (10.12 ± 3.84 years [range: 5-19 years]) and 33 healthy volunteers (10.94 ± 3.78 years [range: 5-19 years]; p > 0.05) were evaluated with a Scheimpflug camera. For corneal densitometric measurements, the cornea was divided into four concentric radial zones and anterior, central, and posterior layers according to corneal thickness. The mean densitometry value for the crystalline lens was calculated in three zones around the center of the pupil.
RESULTS
Corneal light backscattering in all layers and zones of the cornea were similar between the patient and control groups. Lens densitometry values in the three zones did not differ between the two groups (p > 0.05). Maximum lens densitometry values were found to be significantly higher in the patient group (22.14 vs 19.11; p = 0.011).
CONCLUSION
Monitoring the cornea and lens density in patients with FMF using Pentacam may help to show the presence of subclinical inflammation and regulate the follow-up and treatment protocols. Larger sample sizes and prospective design studies are needed to…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 48 participants or records.
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