Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis
Abstract
Background: Polycystic ovarian syndrome (PCOS) has been treated recently with chromium supplementations. However, it is unknown if this dietary supplement has similar effect to metformin.
Aim: The aim of this study was to investigate the efficacy of chromium supplementation in women with PCOS.
Methods: A meta-analysis was conducted using relevant articles obtained from searches of PubMed, Scopus, Embase, and Google Scholar. The mean difference and standardized mean difference were employed to determine the effect size for biochemical parameters.
Results: A total of 10 randomized controlled trials involving 683 women were included in the analysis. The results indicated that chromium supplementation, as vs a placebo, significantly decreased fasting blood insulin (P=0.01), triglyceride (P<0.00001), total cholesterol (P<0.00001), very low-density lipoprotein (P<0.00001), low-density lipoprotein (P=0.0003), high sensitivity C-reactive protein (P=0.02), malondialdehyde (P=0.007), follicle stimulating hormone (P=0.0007), and prolactin (P=0.01), and increased the Quantitative Insulin Sensitivity Check Index (P=0.02), total antioxidant capacity (P<0.0001), and ovulation incidence (P=0.001). Chromium supplementation was also found to be more effective than metformin in reducing HOMA-IR (P<0.00001), and luteinizing hormone (P=0.04).
Conclusion: Chromium picolinate supplementation at a dosage of 200μg may provide benefits similar to metformin with regard to FBG, FBI, ovulation, and…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 683 participants or records.
Read the paper
Related studies
- Metformin as an adjuvant in breast cancer treatment
- Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?
- Aberrant HSF1 signaling activation underlies metformin amelioration of myocardial infarction in mice
- Metformin induces ZFP36 by mTORC1 inhibition in cervical cancer-derived cell lines
- Protein Interaction Network for Identifying Vascular Response of Metformin (Oral Antidiabetic)
- Preventing Long COVID With Metformin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.