Site-specific alterations of bone matrix mineralization, micro-hardness and density of mineralized osteocyte lacunae in men with alcohol-associated liver disease: implications for vertebral fracture predilection
Abstract
Low bone quality has been reported as a source of bone fragility in individuals with alcohol-associated liver disease (AALD). Alterations of the bone matrix, including the spatial bone mineral density distribution and osteocyte lacunar network characteristics, have not been comprehensively assessed in common fracture sites of individuals with AALD. Considering the clinical relevance of vertebral and femoral fragility fractures among these individuals, this cross-sectional study aimed to analyze site-specific bone mineral density distribution, bone mechanical properties, osteocyte lacunar network, and Haversian system characteristics in the first lumbar vertebra and superolateral femoral neck of adult male donors with AALD. Quantitative backscattered electron imaging and Vickers micro-indentation testing were conducted to analyze bone quality in specimens from vertebral and femoral bone harvested at autopsy from adult male donors (n = 24), divided into 2 groups: AALD group (12 individuals with histopathological confirmation of AALD, age: 60 ± 12 yr) and age-matched controls (12 individuals without histopathological features of liver disease, age: 59 ± 12 yr). The comparative assessment revealed significantly lower mean calcium content, reduced Vickers micro-hardness, higher density of osteocyte lacunae occluded with mineralized matter (ie, micropetrosis), thicker osteonal wall, and a higher percentage of osteon refilling in lumbar vertebrae and superolateral femoral neck…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 24 participants or records.
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