Documentation of Intraretinal Retinal Pigment Epithelium Migration via High Speed Ultrahigh Resolution Optical Coherence Tomography
Abstract
PURPOSE To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral domain high speed, ultrahigh resolution optical coherence tomography (OCT) device in a group of patients with early to intermediate dry age-related macular degeneration (AMD). To correlate intraretinal RPE migration on OCT to RPE pigment clumping on fundus photographs. DESIGN Retrospective, non-comparative, non-interventional case series. PARTICIPANTS Fifty-five eyes of 44 patients seen at the New England Eye Center between December 2007 and June 2008 with early to intermediate dry AMD. METHODS 3D OCT scan sets from all patients were analyzed for presence of intraretinal RPE migration, defined as small discreet hyper-reflective and highly-backscattering lesions within the neurosensory retina. Fundus photographs were also analyzed to determine the presence of RPE pigment clumping, defined as black-colored, often spiculated areas of pigment clumping within the macula. OCT en face images were correlated with fundus photographs to demonstrate correspondence of intraretinal RPE migration on OCT and RPE clumping on fundus photo. MAIN OUTCOME MEASURES Drusen, Dry AMD, intraretinal RPE migration, RPE pigment clumping. RESULTS 54.5% of eyes (61.4% of patients) demonstrated intraretinal RPE migration on OCT scans. 56.4% of the fundus photographs demonstrated RPE pigment clumping. All eyes with intraretinal RPE migration on OCT had corresponding RPE pigment…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 44 participants or records.
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