Prognostic significance of calibrated integrated backscatter in patients submitted to transcatheter aortic valve implantation
Abstract
Type of funding sources: None.
There is a reported association between calibrated integrated backscatter (cIB) and myocardial fibrosis, mostly noted in cardiomyopathies and aortic stenosis cases. But whether this measure of myocardial ultrasound reflectivity could help predict outcomes in patients submitted to transcatheter aortic valve implantation has not been previously tested.
To demonstrate whether cIB may help differentiate patients undergoing transcatheter aortic valve implantation (TAVI) at risk of major cardiovascular events.
Consecutive patients submitted to transfemoral TAVI between October 2020 and December 2021 were routinely imaged by echocardiography in the five days peri-procedure. Calibrated integrated backscatter was obtained from the parasternal long-axis view (PLAX) by subtracting pericardial cIB intensity from myocardial septal and posterior wall average cIB. Patients with poor PLAX views were excluded from the study. All measurements of cIB were performed at end-diastole. The primary endpoint was the occurrence of major cardiovascular events at one year of follow-up.
A total of 184 patients underwent a TAVI procedure during the study period. Of these, 159 had a reasonable acoustic window for cIB measurement and were included in the study. Patient mean age was 81.1±6.1 years, and 58% were female. At baseline, 81% of patients had preserved left ventricle function, the mean aortic mean gradient was 44.8±15.1 mmHg, and the mean Euroscore II was 5.55±3.75.…
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