Examination of the effects of ultraviolet radiation on the toxicity of an array of pesticides, polyaromatic hydrocarbons, and pharmaceuticals via in-vitro bioassays
Abstract
External beam radiation therapy has been shown to be an effective treatment method for tumors and abnormalities of the spine and vertebral region. Treating the spine using a stereotactic body radiation therapy (SBRT) technique can reduce toxicity to the spinal cord. The 6 MV flattening filter free (6FFF) beam model is currently used to plan and calculate dose for SBRT treatment plans, and the treatment plans are delivered using a linear accelerator (LINAC). The commissioned beam model represents an invariant component of a LINAC. For volumetric modulated arc therapy (VMAT) treatment plans, the multileaf collimator (MLC) positions are changing throughout the delivery, and variation in these positions can have a large effect on the accuracy of the delivered dose. Since the MLC and jaw positions are patient dependent elements that are implemented as beam modifiers in Elekta Monaco treatment planning system (TPS), post-modeling adjustments to these modifiers can be made to have higher agreement with the delivered dose of the LINAC. With Monaco TPS being implemented as the sole TPS for external beam treatment planning at MBPCC, having high agreement between the TPS beam model calculation and the LINAC delivery is vital to delivering an accurate dose to the patient. Through the delivery and measurement of control plans, the measured dose can be compared against the calculated dose of the TPS to determine whether the plan can be delivered accurately. This also allows for…
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