A new plant-based drug delivery platform based on alkyl polyglucosides and β-sitosterol nanovesicles for topical delivery
Abstract
• Novel nanovesicles without animal-derived components have been developed. • These stable nanovesicles are formed by the self-assembly of β-sitosterol, lauryl glucoside and lauryl glucose carboxylate using the single-step DELOS methodology. • Tocopherol as a hydrophobic model molecule is efficiently loaded in the nanovesicles (49 ± 12 %) maintaining its antioxidant function. • This new nanovesicles are biocompatible with the skin, as evaluated in a 3D epidermal in vitro model. • They enhance the ex vivo skin permeation of a hydrophobic fluorescent probe in terms of time and depth through the epidermis. The finding of new vesicular systems is a challenging process that depends on different factors such as the components used, the interactions between them or the dispersant media. Our objective was to develop a new vesicular delivery system formed by self-assembly of β-Sitosterol (Sit), Lauryl Glucoside (LGL) and Lauryl Glucose Carboxylate (LGC) molecules, all plant-based, biodegradable and biocompatible components. Nanovesicles (NVs) with different molar ratios of Sit, LGL and LGC were prepared using a single step method named DELOS, and characterized by dynamic light scattering, cryo-electron microscopy and small-angle X-ray scattering. Antioxidant compound α-tocopherol (TCP) was integrated in the NVs showing their potential to nanoformulate hydrophobic payloads. Finally, in vitro biocompatibility assays with reconstructed human epidermis and ex vivo skin retention studies…
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