A real time solid state dosimetry system for QA in synchrotron x-ray microbeam radiosurgery
Abstract
Microbeam radiation therapy (MRT) is an experimental radiosurgical technique under investigation as a treatment for presently incurable brain lesions such as gliomas. The treatment involves the irradiation of a macroscopic target volume by delivering a very high dose to many microscopic wide sub-volumes. A very high dose rate and very low beam divergence are prerequisites for MRT, which at present necessitates the use of synchrotron radiation. The complex structure of the radiation field combined with the very high dose rate pose a challenge for conventional dosimetry. To address the dosimetric inadequacies, a complete and standalone dosimetry system was developed for MRT as part of this work. It includes the silicon microstrip detector: a high spatial resolution single strip detector, data acquisition hardware capable of remotely biasing and reading out the detector, and data acquisition software to interface with the hardware and perform analysis on received data. The system is collectively known as X-tream.\nThis thesis provides an introduction to MRT, the production of synchrotron X-rays and a literature review of methods of dosimetry for MRT as reported in literature. The development of the X-tream system is discussed along with an overview of its operation and initial characterisation.\nCharge-collection characterisation of the microstrip detector was performed in numerous ways. Alpha spectroscopy reveals that the application of the guard ring greatly reduces the…
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