Study of drug-excipient interactions regarding solubility enhancement in diluted aqueous media and solid state transformations
Abstract
Nearly all marketed dosage forms comprise pharmaceutical excipients that have multiple functions, for example, improvement of wettability, solubilization, or absorption enhancement, while they can also have further technical functions such as diluent, glidant, disintegrant, or preservative. The selection of appropriate excipients is crucial for a suitable dosage form design and therefore an important step during the drug development process. Excipients have traditionally been considered as pharmacologically inert; however, they can interact with the drugs in the dosage form. Such interactions can be of physicochemical nature or even biological effects may occur that are critical for oral drug absorption. These interactions can be especially of relevance when formulating poorly water-soluble drugs. Different formulations are needed for the various development phases, where eventually different requirements have to be considered. In early phases, time lines and drug amounts are very limited and therefore, formulation development has to be fast and compound saving but long-term stability does not have to be given. Since the choice of excipients is such a crucial step, a better mechanistic understanding is targeted by pharmaceutical scientists to avoid a purely empirical trial-and-error approach. A thorough general mechanistic understanding of drug-excipients interactions is helpful for designing a robust formulation. \nIn academic and industrial research, there is a huge…
How strong is the evidence?
Evidence Hub reads this as a thesis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Characterization and Analysis of Porosity and Pore Structures
- Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?
- Dental Optical Coherence Tomography
- Radiation-shielding concrete: A review of materials, performance, and the impact of radiation on concrete properties
- Testing entanglement of annihilation photons
- Calanus finmarchicus seasonal cycle and diapause in relation to gene expression, physiology, and endogenous clocks
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.