Levofloxacin-Induced Generalized Fixed Drug Eruption
Abstract
Fixed drug eruption (FDE) is a type of toxicodermatitis induced by a delayed hypersensitivity reaction (type IV) characterized by the reappearance of erythematous-violaceous plaques at the same site upon reexposure to the triggering agent. We present the case of a 72-year-old female who developed a generalized FDE following the administration of levofloxacin. Diagnosis was established clinically and supported by the Naranjo algorithm. The condition improved upon drug discontinuation. This case highlights the importance of recognizing less common presentations, such as generalized FDE, and the need for continued awareness among healthcare providers, especially given the frequent use of antibiotics like levofloxacin.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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