Antagonistic effect of increasing dietary zinc on the efficiency of microbial phytase on calcium, phosphorus, and zinc digestibility and status in pigs: a meta-analysis
Abstract
Dietary zinc (Zn), phytate, calcium (Ca), and microbial phytase (PhytM) interact in the gastrointestinal tract of pigs, which determines the utilization of phosphorus (P), Ca, and Zn. Previous studies have assessed the impact of Zn and PhytM on Zn status by measuring apparent total tract digestibility (ATTD) of Zn and plasma Zn concentration in pigs, and some of these studies also measured P and Ca ATTD. The objectives of this meta-analysis were to quantify the effect of Zn, PhytM and their interactions on (1) digestible P and Ca content (g/kg diet) and (2) digestible Zn and Zn ATTD (%) and plasma Zn status. To investigate these objectives, an exhaustive literature search was made to create two sub-databases: (1) Ca-P database containing 52 treatments, from postweaning pigs and using pharmacological Zn doses (> 1 000 mg Zn/kg), and (2) Zn database of studies from postweaning and grower pigs with dietary Zn concentration 1 000 mg Zn/kg) to postweaning pigs decreased the ATTD of P and Ca. Moreover, the positive effect of PhytM on the digestible content of Zn, P, and Ca as well as on plasma Zn, was dependent on dietary Zn concentration.
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Evidence Hub reads this as a meta-analysis, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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