Induced diabetic neurogenic bladder animal models: application characteristics and standardization proposals via systematic data mining
Abstract
Background: Diabetic Neurogenic Bladder (DNB) is a prevalent urological disorder and autonomic nervous system complication associated with diabetes mellitus. This condition may lead to severe renal damage if not properly managed. Despite its clinical significance, there is a lack of unified standards for current DNB animal models, and previous review articles fail to provide sufficient objective data to support their conclusions.
Objective: The present study aims to systematically summarize the characteristics of DNB animal models through data mining techniques, thereby offering a theoretical reference for the establishment of standardized DNB animal models.
Method: Relevant studies were searched in 7 databases including PubMed and CNKI. After screening in accordance with the PRISMA flow diagram, a total of 352 eligible studies were included in the analysis. The SYRCLE tool was employed for quality assessment of the included studies, while SPSS Modeler (utilizing the Apriori algorithm) and R software were used for statistical analysis and result visualization.
Results: SD rats, Wistar rats, and C57BL/6 mice were identified as the primary animal species used for constructing DNB models, with male animals accounting for 82.39% of the total. Chemical induction (predominantly streptozotocin, STZ; 74.15%) and combined induction with STZ plus a high-sugar and high-fat diet (13.64%) were the mainstream modeling methods. The most commonly used STZ dose was 60 mg/kg (administered as…
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Evidence Hub reads this as a systematic review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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