Adsorption of Levofloxacin onto Graphene Oxide/Chitosan Composite Aerogel Microspheres
Abstract
The removal of pharmaceutical residues from water resources using bio-based materials is very important for human safety and health. Bio-based graphene oxide/chitosan (GO/CS) aerogel microspheres were fabricated with emulsification and cross-linking, followed by freeze drying, and were used for the adsorption of levofloxacin (LOF). The obtained GO/CS aerogel microspheres were characterized with scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and thermogravimetry (TG). The effects of GO content, pH value, and temperature on their adsorption capacity were investigated. With the incorporation of 40 wt% GO, the adsorption capacity increased from 9.9 to 45.6 mg/g, and the highest adsorption capacity, 51.5 mg/g, was obtained at pH = 8 and T = 25 °C. In addition, to obtain deeper insight into the adsorption process, the thermodynamics and kinetics of the process were also investigated with four different models of LOF adsorption. The thermodynamic modeling results revealed that LOF adsorption is exothermic, and the kinetic investigation demonstrated that LOF adsorption is generally consistent with a pseudo-first-order rate law.
Read the paper
Related studies
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Photochemical behavior of levofloxacin
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio
- Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
- Synthesis of [11C]levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.